Meet Korea's Latest Skincare Trend: PDRN (aka... Salmon Sperm?)
If you've been keeping up with the latest K-Beauty buzz, you've probably noticed one ingredient popping up everywhere lately: PDRN. Short for polydeoxyribonucleotide (say that five times fast!), this powerhouse ingredient is derived from salmon DNA and is loved for its incredible healing and anti-inflammatory benefits.
You might've seen the term floating around in headlines about celeb-loved "salmon sperm facials" (yes, really)—but don't worry, PDRN-infused skincare offers a much more approachable (and needle-free!) way to enjoy the glow. Thanks to Korea's game-changing innovation, you can now find PDRN in everything from serums and ampoules to moisturisers and toners.
Scroll through #KBeautyTok and you’ll see the hype is real—glassy skin, a stronger moisture barrier, and that lit-from-within radiance everyone's chasing. But does it live up to the glow? And more importantly, is it the right match for your skin? Let's break it down.
What is PDRN — and why is it so buzzworthy?
PDRN (polydeoxyribonucleotide) is a DNA fragment—usually sourced from salmon sperm DNA. While that might sound a little out there, this ingredient has actually been used in medicine for decades. First studied in the 1980s for its regenerative properties, PDRN has been used to treat wounds, burns, and even diabetic ulcers, thanks to its ability to promote cell growth, reduce inflammation, and accelerate tissue repair.
And for those seeking vegan alternatives, there are now bio-synthetically derived versions of PDRN. While they may not yet fully replicate the efficacy of the original, rapid advances in biotech are closing the gap—making the glow more accessible for everyone!
Why Your Skin Will Love PDRN:
-
Boosts repair & healing
PDRN stimulates fibroblast activity, encouraging collagen production and faster tissue recovery—ideal for smoothing over acne scars or skin barrier damage. - Calms redness & inflammation
With potent anti-inflammatory effects, it soothes stressed or irritated skin—including post-treatment sensitivity from microneedling or laser sessions. - Enhances elasticity & smoothness
Regular use of topical PDRN can refine texture, reduce fine lines and leave skin firmer and more supple. -
Brightens & targets pigmentation
It helps fade hyperpigmentation and evens skin tone—great if you're chasing that glass‑skin look. -
Deep hydration & barrier strength
Whether it's salmon-derived or plant-based (like ginseng PDRN), it delivers deep hydration, plumping out the complexion and reinforcing the skin's moisture barrier.
Should you try it?
If you're all about glow, healing post‑acne scars or hyperpigmentation, or want to elevate your barrier and bounce, PDRN could be your next skin obsession. Especially if you're already into K‑Beauty rituals or curious about cosmetic‑grade actives without needles. Just make sure to choose a formula that suits your vibe, and commit to at least 6 weeks of use!
The Best PDRN Skincare Products for You to Try!
1. Medicube PDRN Pink Peptide Serum
When it comes to PDRN-infused serums, this viral formula from Medicube is easily one of our top picks. Also packed with skin-loving ingredients like Peptides, Niacinamide, and Adenosine, it works hard to brighten dull skin, deeply hydrate and strengthen your moisture barrier—while giving your skin that firm, bouncy feel we all love.
2. VT Cosmetics PDRN Essence 100
While most research centers around Salmon-derived PDRN, early studies suggest that Ginseng-based PDRN also offers impressive skin-regenerating benefits. This top-rated essence from VT Cosmetics features a potent 10% Ginseng PDRN concentration that absorbs beautifully into the skin, paired with barrier-loving Ceramides to keep your complexion calm, hydrated and resilient.
3. Anua PDRN Hyaluronic Acid Capsule 100 Serum
If you have dry or dehydrated skin, you might want to turn to this formula from Anua, which is infused with 100ppm PDRN and Smart Capsule Technology to deliver deep hydration. This serum can be easily incorporated into your daily skincare regimen, leaving your skin radiant, smooth and plump.
4. Genabelle PDRN Rejuvenating Toner
On the hunt for a replenishing toner to soothe and revive sensitised skin? This formula from Genabelle is like a tall drink of water for your face—instantly hydrating and nourishing to help banish dryness and dullness. With skin-loving ingredients like Panthenol, Beta Glucan and Niacinamide, it also works to smooth texture and visibly even out your skin tone for that healthy, lit-from-within glow.
5. Heveblue Salmon Caring Centella Ampoule
If your skin tends to be extra sensitive, this PDRN-infused ampoule from Heveblue is a soothing standout. Instead of plain purified water, it’s powered by a calming trio of Centella Leaf Water, Madecassoside and Portulaca Oleracea Extract—all working together to reduce redness, calm irritation and shield your skin from everyday stressors.
6. Abib PDRN Collagen Lip Mask Glazed Jelly
Say hello to your new go-to for juicy, pillowy lips—day or night. The Abib PDRN Collagen Lip Mask Glazed Jelly is a multi-tasking treat that works as a sleeping mask, gloss and hydrating balm in one. Infused with plant-derived PDRN and 3D Collagen, it helps restore moisture and elasticity for visibly plumper, smoother lips.
7. Medicube PDRN Pink Collagen Gel Mask
Whether you're winding down for the night or gearing up for a long-haul flight, this PDRN-infused gel mask from Medicube is your skin's ultimate reset. Packed with low-molecular Hydrolyzed Collagen, it sinks deep to boost elasticity and restore radiance in just a few hours. As the mask turns transparent, it works its magic—leaving your skin noticeably smoother, plumper and glowier.
